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 Issue
020 |
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Double whammy
Laboratoria Smeets
In collaboration with Ghent University, Labo Smeets has developed a new technology
that enables the continuous production of water-soluble granules. Managing director
Jef Verplaetse explains how twin screw extruders can improve the bioavailability
of medicines that are not easily soluble in water. more... |
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Chew and deliver
Cafosa Gum
Medicated chewing gum, launched in 1928, is becoming increasingly popular as a method
for drug delivery. Aliasgar Shahiwala of the Dubai Pharmacy College explains the
benefits for the pharmaceutical industry. more...
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A quality combination
RAUMEDIC
Combining 60 years' experience with the dynamism of a young and flexible company,
RAUMEDIC provides the highest quality systems, components and services. Dr Thomas
Jakob explains to Abi Millar how RAUMEDIC tailors its products to meet its clients' needs.more... |
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 Issue
019 |
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Powder
to the people
Cafosa
Pharmaceutical companies are often wary of drug
delivery via medicated chewing gum due to the complex
manufacturing processes involved. But, as Cafosa’s
Roser Amposta explains to World Pharmaceutical Frontiers,
the organisation’s gum product range offers
an innovative way to produce medicated chewing gum
simply and cost-effectively. more... |
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On
top of packaging
Dividella
More pharmaceutical products are produced in parenteral
form, which boosts demand for topload packaging
solutions. Dividella’s Manfred Zurkirch explains
how the company produces strong, cost-effective
packaging and extends the lifecycle of manufacturing
machinery. more... |
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Power
of partnerships
GE Healthcare
Positron emission tomography has become an important
way to monitor therapies, but the trend towards
molecular technologies has forced companies to expand
their remit to maintain customer satisfaction. Eric
Agdeppa, GE Imanet, explains how partnerships have
created new competencies in anti-body fragments
and non-imaging biomarkers. more... |
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Pen
injector technology meets design
Haselmeier
Haselmeier is a leading designer and manufacturer
of pens and auto-injectors for injectable pharmaceuticals.
more... |
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Absorption
rate boost for transdermal applications
LTS Lohmann
LTS Lohmann Therapie-Systeme has developed a product
that has an increased absorption when released to
the skin compared to natural isotope methods. more... |
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Therapy
monitoring and personalised mediciney
Micrel
Intravenous catheters infuse drugs into the body
and can send back information about the effects
of the infusion so that the drug therapeutic index
can be increased by controlling infusion parameters.
Alexandre Tsoukalis, Micrel Medical Devices, describes
an alternative way to trial phases of a drug where
its dose prescription depends on the feedback reading,
not on age and weight. more... |
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 Issue
018 |
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Oral
drug delivery for the 21st century
LTS Lohmann Therapie-Systeme
In this age of scientific and technological advance,
one company is ready to take the delivery of oral
drugs to the next level. LTS Lohmann’s Dr Keith
Jensen has a vision of the future. more... |
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No
more needles
Crossject
For those who hate needles, Crossject’s new
product Zeneo will be a welcome relief. It is a
needle-free, pre-filled, single-use injection device.
Bruno Besse, MD Director Medical Affairs scratches
the surface. more... |
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Coat
tales
Evonik
With PlasACRYL T20, Evonik has found an innovative
way to make coating easier and more efficient, improving
the quality of your tablets. more... |
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Powder
to the people
Cafosa Gum SAU
Pharmaceutical companies have often been wary of
drug delivery via medicated chewing gum due to the
complex manufacturing processes involved. But, as
Cafosa’s technical director Roser Amposta explains
to World Pharmaceutical Frontiers, the organisation
has developed Health in Gum, which offers an innovative
way to produce medicated chewing gum simply and
cost-effectively. more... |
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 Issue
017 |
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Developing
a cure for protein stability
Do-coop technologies
An ordered aqueous solution that mimics in-vivo
conditions may prove to be the cure for the instability
and reduced bioactivity that afflicts many protein-based
therapeutic formulations. more... |
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Predictable
behaviour of drugs
TNO
Pharmaceutical companies are looking to predict
the behaviour of drugs earlier and earlier in the
development phase, making subsequent human trials
more efficient and saving time and money. TNO, an
independent research organisation, is offering innovative
solutions. more...
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Health
in gum
Cafosa
Chewing gum is an excellent alternative to traditional
drug delivery methods. Cafosa has developed Health
in Gum, to make the production of medicated chewing
gum easier, says technical director Roser Amposta.
more... |
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Needle
free injection
Crossject
Using technology similar to that used in airbags,
Crossject’s new injection device circumvents
needle phobia and reduces the risk of needle-stick
injury. more... |
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Pen
sized dose delivery
Haselmeier
Haselmeier is a leading designer and manufacturer
of pens and autoinjectors for injectable pharmaceuticals.
For 40 years the company has combined experience
and innovation to produce disposable and re-usable
self-injection delivery systems, many featuring
its hidden needle design. more... |
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Pharmaceutical
partners
Cimalabs
CIMA® is a world leader in the drug delivery
partnering business, specialising in the formulation,
tastemasking and manufacturing of pharmaceuticals
using its orally disintegrating tablet (ODT), oral
transmucosal, tamper-deterrent, solubilisation and
oral powder drug delivery technologies. more... |
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A
quick solution
Alpex pharma
Fast melt technology allows tablets to be taken
any time, anywhere, without water. The development
and commercial manufacture of fast melt, orodispersible
tablets (ODT), along with effervescent technology,
are at the forefront of focus for Swiss drug delivery
company Alpex Pharma. more... |
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 Issue
016 |
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Multi-component
moulding experts
RAUMEDIC
Safety is essential in the pharmaceutical
industry, so products that retain their structure
and original qualities should be a specific focus
for all manufacturers. more...
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Research
and development experts
Eurand
A wide range of capabilities and a unique business
model has drawn talent to a speciality pharmaceutical
company. more...
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Revolutionary
water-based nanotechnology
Do-Coop Technologies Ltd
Do-Coop’s Neowater solution for hydrating
poorly performing drug compounds opens and widens
the therapeutic window, allowing the entry of poorly
soluble compounds into the intellectual properties
portfolio, solving one of the major challenges the
pharma industry faces. The company’s Eran
Gabbai and Regina Nadborny explore the product’s
benefits. more...
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 Issue
015 |
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Rock-solid
stability
Soliqs
Melt extrusion technology can add value to the formulation
of new molecular entities and established products.
SOLIQS’ Meltrex technology has been developed
by combining expertise in the fields of pharmaceuticals,
polymer chemistry and analytical techniques.
more... |
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The
aerosol challenge
DuPont
Patient safety remains the number one priority when
it comes to drug delivery and that includes the
production of a non-CFC aerosol. DuPont has produced
a number of CFC alternatives in the search for the
perfect pharmaceutical propellant. more...
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Increasing
demand for controlled release
Penwest
PharmaceuticalsDespite the investment focus on internal
product development, established flexible oral controlled-release
technologies by specialist companies retain key
advantages and benefits, particularly as many drugs
remain difficult to formulate and differentiate.
more...
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Solving
solubility
Eurand
The insoluble nature of some compounds prevents
the oral dosing of the treatments they enable. Innovation
and precision engineering in equal measures have
now overcome that problem, so that insolubility
is no longer a barrier to oral delivery. more...
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Intradermal
injections made easy
Becton Dickinson
Traditional injection methods are awkward to use
and often lead to misinjections. The time has come
for an innovative microinjection system that delivers
the right dose in the right place. more...
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Gum
technology
Fertin Pharma A/S
The technologies of the medical chewing gum MediChew®
offer several advantages to the patient: buccal
absorption facilitates fast uptake of the API and
reduces possible adverse side effects, such as stomach
ache or vomiting, related to the intake of a tablet.
more... |
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 Issue
014 |
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Unlocking
the intradermal route
BD
The Mantoux technique, the traditional
method of delivering therapies by injection through
the skin, is difficult to use and prone to mis-injection.
BD Soluvia™ is an innovative microinjection
system that allows simple and reliable intradermal
injection. more...
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Focus
on quality and value
Forteq
The demands on drug delivery and self-diagnostics
devices are growing, but manufacturers of high-precision
components are offering device companies better
quality and value. This is the message major pharma
wants to hear. more...
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The
aerosol challenge
DuPont
Patient safety remains the number one priority
when it comes to drug delivery and that includes
the production of a non-CFC aerosol. DuPont has
produced a number of CFC alternatives in the search
for the perfect pharmaceutical propellant. more...
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 Issue
013 |
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Smart
solution to challenging compounds
SOLIQS
More drug makers are turning to melt extrusion technology
as a low risk way of formulating drug molecules
with challenging profiles. A unique alternative
has been developed that will add value to the formulation
of both new molecular entities and established products.
more... |
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Value
for brands and patients
Meldex International
Pharmaceutical products need to be immediately effective:
for consumers and for manufacturers requiring brand
protection. Polymer technology provides a simple
anti-counterfeiting system that has instant absorption
capabilities.
more... |
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New
life for drug compounds
Eurand
Drug solubility is an important factor influencing
the rate and extent of drug absorption, therefore
determining the overall bioavailability. Bioavailability
technologies offer solutions that overcome the challenges
of poor drug solubility.
more... |
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Oral
controlled release technologies
Penwest Pharmaceuticals
In an era where formulation challenges are increasingly
common, established, flexible, oral controlled release
technologies are important tools for creating approvable,
innovative products.
more... |
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 Issue
012 |
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ODT:
simple and effective
Eurand Pharmaceuticals
The efficacy of any treatment depends on patients’
compliance with their regimen. Reducing the number
of doses and offering medication in a form that
is easy to take can positively affect patient behaviour.
The next generation of orally disintegrating tablets
combines these benefits in one, simple product.
more... |
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 Issue
010 |
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Patient-friendly
ODTs
Eurand
Many tablets are hard to swallow: they
are bitter tasting, disintegrate slowly and do not
take effect for about an hour after administration.
One company has worked to successfully overcome
these challenges. more... |
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Streamlining
ODT technology
Developing orally disintegrating tablets
can be expensive due to their complex dosage forms.
Two platforms are available that aim to improve
the manufacturing process. more... |
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Delivering
excellent products and services
Cardinal Health
Cardinal Health is a global leader in development,
drug delivery technologies, contract manufacturing,
packaging and product commercialisation services,
serving the worldwide pharmaceutical and biotechnology
industries. more... |
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Developing
greener and more effective inhalers
DuPont
The challenge of developing more environmentally
friendly inhalers has provided the perfect opportunity
to improve current formulations of pharmaceutical
aerosols. more... |
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 Issue
009 |
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Intelligent
nasal drug delivery
Kurve Technology, Inc
Current drug delivery systems track and validate
prescription drugs from manufacturer to retailer,
thereby curtailing fraud. However, the industry
also requires systems that validate the product
at patient level to avoid drug misuse. more... |
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Engineering
intelligence for high-volume production
Mikron Plastics Technology
Producing small complex plastic components in high
volumes can be a difficult process. Luckily, expert
knowledge is readily available. more... |
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 Issue
008 |
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Pulmonary
delivery – the next wave
Nektar Therapeutics
The outlook is increasingly promising for products
that deliver medicines to and through the respiratory
system. more... |
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Layering
nanocapsules and microcapsules
Capsulution NanoScience AG
A large amount of pharmaceutical R&D resources
are being spent on enhancing the delivery properties
of existing and new drugs. Over the last years,
an extended research community has been built around
the use of innovative formulation processes. One
of these new formulation processes, which have seen
promising advances is called LBL-Technology®.
more...
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Needle-free
injectors evolve
Crossjet SA
There is now much more interest in needle-free
technologies, as more sophisticated solutions reach
the market. Manufacturers hope that customers will
take a long-term view of costs, as there is value
behind the higher purchase price of needle-free
injectors.
more... |
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Measured
in numbers
SI Associates Ltd
'I often say that when you can measure what you
are speaking about, and express it in numbers, you
know something about it.' more... |
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Related
articles from this issue |
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|
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 Global
Alliance Development
Alliances are becoming more common in the
pharmaceuticals industry. The Global Discovery Alliances
team at AstraZeneca reveal the merits such ventures
have in contributing to the success of a company’s
business strategy. |
|
 Issue
007 |
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Alginate,
chitosan and hyaluronan in drug delivery
FMC BioPolymer
By Dr Michael Dornish, VP research and development,
and Dr Are Kristiansen, commercial development manager,
at FMC BioPolymer...
click here
for more |
