Drug formulation and developmentTop
Supercritical fluid technologies
Supercritical fluid technologies (SCF) have grown in popularity in recent years, due to their low impact on the environment as well as their ability to streamline development and save costs. Among all the SCF-assisted processes for particle formation, the solution-enhanced dispersion by supercritical fluids (SEDS) process is one of the most efficient methods for drug development. World Pharmaceutical Frontiers speaks to Ranjith Kumar Kankala from Huaqiao University in China about the current and future applications of this technology.
Drug delivery devices for biosimilars and biologics
The personalised medicines era is shifting the focus of pharmaceutical development and manufacturing activities from small molecules to biologics. However, due to their complex macromolecular structure, these biopharmaceuticals are more complex to deliver. World Pharmaceutical Frontiers speaks to Corinna Sonderegger, head portfolio management device development and commercialisation at Novartis, about recent developments in drug delivery, including how to tackle the challenge of intravitreal injections.
Market evolution of needle-stick prevention systems to meet regulatory requirements
More than one million needle-stick injuries occur in the EU each year, with an associate of approximately £141 million. However, most of these are preventable by ensuring that needle-stick prevention systems are put in place. World Pharmaceutical Frontiers speaks to Donna French, executive director of commercialisation at Amgen, about the regulations for needle-stick prevention as well as the latest developments to ensure the safety of products is maximised.
Chemicals and raw materialsTop
The business of medical cannabis
Over half of the states in the US now have legalised cannabis in some form, and since November 2018, can be prescribed by the NHS in the UK for certain conditions, such as epilepsy. However, due to the rapidly evolving variations in the regulatory landscape, navigating this market can be fraught with challenges. Nic Easley, founder and CEO of 3C consulting, speaks to World Pharmaceutical Frontiers about the key considerations to overcome these hurdles when developing medicinal cannabis products.
In recent years biotech clusters have become an increasingly important part of pharmaceutical companies’ research and development strategies. Top biopharma clusters come down to dollars and cents, and more of those resources are increasingly concentrated in fewer places. Martino Picardo, CEO at Stevenage Bioscience Catalysts, speaks to World Pharmaceutical Frontiers about the potential of these biotech clusters to address increasing cost and commercial pressures.
Pharma 4.0: recent trends and developments
A lot has been written on Big Data and the Industrial Internet of Things (IoT) – also known as Industry 4.0 – and how it’s rapidly transforming a number of different sectors. However, much less attention has been paid to how industry 4.0 solutions can be applied to pharmaceutical manufacturing. World Pharmaceutical Frontiers speaks to Miran Denac, vice-president of Operations Germany and Western Europe Cluster at TEVA, about how these technologies can improve quality and productivity, whilst minimising waste and risks.
Packaging artwork: meeting regulations and patient needs
The largest single cause of product recall is due to packaging errors. Despite its significance, packaging artwork is an often forgotten aspect of the manufacturing process. Michael Fritz, director of global labelling at Abbott, discuss how to optimise artwork to support serialisation and improve patient interaction.
Child resistant packaging: a sector in its own right
Meeting both regulatory and patient needs in the packaging of pharmaceuticals can be very challenging for manufacturers, especially in the case of child resistant packaging (CRP). There are a number of legislative, testing, and certification demands to consider. World Pharmaceutical Frontiers speaks to Stephen Wilkins, CEO of the Child Safety Packaging Group to discuss how to ensure these requirements are met.
Supply chain and logistics supplementTop
The internet of things and smart sensors
The IoT offers huge potential to improve efficiencies across the supply chain. Technologies like smart sensors provide relevant, real-time data about products and conditions, facilitating the ability to respond quickly and anticipate future issues. Joseph Fitzgerald, principal of supply chain and manufacturing operations at Deloitte, explains the integration of IoT into existing systems and how to maximise the technological benefits.
Blockchain in serialisation and traceability
Blockchain has already been implemented in the supply chain and procurement processes of several industries, such as diamonds and produce. However, implementation of electronic serialisation is needed before blockchain can be adopted by the pharmaceutical industry. Blockchain cannot be used to label actual drug products but it can be implemented using a two-dimensional barcoding system to authenticate containers throughout the supply chain. We speak to Pasi Kemppainen, management adviser of serialisation and traceability at Santen Pharmaceutical, about the benefits and risks of blockchain for the industry.
Track and trace implementation in a mid-size contract packaging organisation
Due to globalisation, the supply chain for medicines has become lengthier with every step, offering more opportunities for counterfeiting to take place. Track and trace requirements have thus become more stringent, which can be particularly challenging for mid-size organisations to implement. World Pharmaceutical Frontiers talk to Matthias Korbl, co-general manager and head supply chain management at Siegfried Pharma AG, about how to integrate track and trace whilst balancing cost efficiencies and customer requirements.
Air freight for the cold chain
Transporting pharmaceutical products by air requires complex logistical processes, specific equipment, storage facilities and harmonised handling procedures to maintain shipment integrity. Building a network of certified pharmaceutical trade lanes that meet consistent standards and assure product integrity is a key strategy to optimise air freight. Francisco Rizzuto, cargo specialist manager for Europe IATA, speak to World Pharmaceutical Frontiers about the value of collaboration to maximise the benefits of air freight for the cold chain.
Temperature controlled supply chain in emergency situations
With the huge number of influential factors and the sensitivity of products to temperature, controlling the cold chain is inherently challenging. This difficulty is exacerbated when natural disasters occur, either in the short or long term. Ruud van der Geer, associate director of supply chain management EMEA, MSD speaks to World Pharmaceutical Frontiers about how information and technology can best be used to avoid temperature excursions in these situations.