Oryzon Genomics, S.A. (ISIN Code: ES0167733015, ORY), a clinical-stage biopharmaceutical company leveraging epigenetics to develop therapies in diseases with strong unmet medical need, announced today that it has received “Decision to grant” communications from the Japanese Patent Office (JPO) for two Japanese patent applications related to vafidemstat, Oryzon’s LSD1 inhibitor in clinical development for the treatment of psychiatric disorders like BPD and schizophrenia. These two patent applications are JP2021-556616 entitled “Methods of treating borderline personality disorder” and JP2021-556629 entitled “Methods of treating attention-deficit hyperactivity disorder using KDM1A inhibitors such as the compound vafidemstat”. The allowed claims cover the use of vafidemstat for the treatment of BPD and ADHD, respectively.
The Decision to grant is a formal communication from the JPO in which it indicates that a patent application has reached the status where it is allowed for issuance as a patent. Both patents, once granted, will not expire until at least 2040, excluding any potential patent term extensions that may provide additional protection. Corresponding patent applications are pending in several additional major pharmaceutical markets.
Oryzon had recently received Decision to grant communications from the European and Korean patent offices for additional important patents for vafidemstat, covering its use for the treatment of aggression and social withdrawal. A corresponding patent has already been granted in Russia.
“We are delighted to have obtained allowance for these two Japanese patent applications, which further strengthen the multiple layers of protection we have built around vafidemstat”, said Neus Virgili, Oryzon’s Chief IP Officer.
“Our growing intellectual property portfolio reinforces the unique value proposition for vafidemstat, extending substantially its commercial life in CNS indications with large market potential like BPD or ADHD”, stated Dr. Carlos Buesa, Chief Executive Officer of Oryzon.