Verismo Therapeutics, a clinical-stage CAR T company, Penn spinout, and pioneer of the novel KIR-CAR platform technology, today announced that it had entered into a licensing agreement with the University of Pennsylvania for worldwide exclusive rights for two newly discovered anti-CD19 binders.

The newly discovered binders are a result of the sponsored research agreement between Verismo and the University of Pennsylvania that was executed in 2022. Donald Siegel, MD, PhD’s lab utilized his state-of-the-art phage display technique to discover two anti-CD19 binders with high activity. Verismo will utilize one of these binders, DS191, as the basis for its SynKIR-310 product, a KIR-CAR T cell immunotherapy therapeutic for blood cancer, while reserving both binders for potential future partnering.

“Our team at Verismo is thrilled to announce the discovery of these two groundbreaking anti-CD19 binders,” said Dr. Laura Johnson, Chief Scientific Officer at Verismo. “These findings have the potential to significantly impact the field of immunotherapy, allowing us to develop more precise and effective treatments for patients in need.”

With its pioneering capabilities in binder discovery for cell therapy, Verismo is at the forefront of driving innovation and success in this transformative field. Their commitment to excellence, research-driven approach, and dedication to supporting client needs position them as an invaluable partner for companies and institutions involved in advancing cell-based therapies.

Verismo plans to submit an IND for its SynKIR-310 product, which utilizes the DS191 binder, by the end of 2023 and to seek collaborations with key industry partners. Moving forward, Verismo also plans to initiate discovery of binders towards additional immune-oncology targets.

“We are thrilled to unveil the groundbreaking discovery of two novel CD19 binders,” said Dr. Bryan Kim, CEO of Verismo. “As we move forward, we are eager to forge strategic partnerships with like-minded organizations who share our vision for advancing precision medicine. Together, we can harness the potential of these CD19 binders to develop transformative therapies that provide targeted and personalized solutions to patients in need. We welcome collaboration opportunities and look forward to shaping the future of cancer treatment through innovative partnerships.”