Crossject - Advanced development: Zeneo's needle-free injections

For patients, ZENEO® enables the simple, rapid, needle-free, intramuscular or subcutaneous self-administration of treatments in a 'readyto- fill' package.

ZENEO®, a compact, user-friendly device is simple to use, fast (50ms) and the dose injected is pre-set. The patient self-administers the right drug at the right dose, safely and with a minimum of discomfort.

The company's portfolio currently contains eight products in advanced stages of development, seven of which are for urgent or life-threatening situations, such as adrenaline for anaphylactic shock, midazolam for epileptic seizures, naloxone for opioid overdose, hydrocortisone for acute adrenal insufficiency and terbutaline for severe asthma attacks.

'Ready-to-fill' glass containers

In 2017, Crossject launched its new production facility in Dijon, France, which is dedicated to the manufacture of siliconised, depyrogenated, sterilised pharmaceutical-quality glass tubes. The manufacturing process behind producing the 'ready-to-fill' tubes begins with washing of the glass tubes, before coating with a silicone emulsion, heating and depyrogenation and, finally, performing moist heat sterilisation. A huge advantage is that tubes can then be filled without further processing.

The patient self-administers the right drug at the right dose, safely and with a minimum of discomfort.

Baked-on siliconisation technology

ZENEO® uses a lubricant to enable the stoppers to move properly through the glass tube. To ensure a very high quality of lubrication with excellent performance, Crossject chose to use a pharmaceutical silicone emulsion and baked-on siliconisation technology.

It involves coating with silicone oil as an emulsion that is then baked on to the glass surface in an oven at a specific temperature for an appropriate time. In the baked-on process, part of the silicone oil is not removed with solvent and a permanent hydrophobic layer is created. Compared with oily siliconisation technology, baked-on technology reduces the measurable quantity of free silicone oil.

Reducing interaction

Consequently, chemical reactions with the solution contained in the glass tube is reduced. Another improvement is the quantity of subvisual and visual silicone oil particles in a solution that is also reduced. By reducing product-silicone interaction and particle contents, benefits include improvements of compatibility, stability and security.

Sterilisation technology

There are several modes of sterilisation that can be used for primary packaging of injectable devices, and ethylene oxide is widely used in industry. This solution presents toxicological risks highlighted for several years by the health authorities: in particular, because of the presence of residues adsorbed on the material - mainly on plastics.

Authorities wrote guidance on limitating the use of ethylene oxide in the manufacture of medicinal products and specifications on residues. To avoid this risk and in the interest of patient safety, Crossject chose to use glass tubes and to sterilise by a process of moist heat in an autoclave. During all the development of ZENEO®, Crossject pays particular attention to driving its innovations using high-quality technologies and processes.

Products and Services

Contact Details

6 Rue Pauline Kergomard, 21000 Dijon
Tel: +33 (0)3 80 54 98 50 (Dijon) or +33 (0)3 63 74 80 03 (Gray)
Tel: +33 (0)3 80 54 98 50

For patients, ZENEO® enables the simple, rapid, needle-free, intramuscular or subcutaneous self-administration of needed treatments in a ready-to-use package.
The administration of a medication with ZENEO® involves only two simple steps: 1. Removal of the safety cap, which automatically breaks the sterility seal.
2. Placement of the device on the skin surface and a push to inject the formulation in less than a tenth of a second.
The actuator activates the generator and the resulting gas propels the liquid formulation at a very high speed. The first phase allows the product to cross the skin and the second diffuses the treatment at the desired depth, all within a tenth of a second.
Make An Enquiry
First Name

Last Name

Email Address


Privacy Policy
We have updated our privacy policy. In the latest update it explains what cookies are and how we use them on our site. To learn more about cookies and their benefits, please view our privacy policy. Please be aware that parts of this site will not function correctly if you disable cookies. By continuing to use this site, you consent to our use of cookies in accordance with our privacy policy unless you have disabled them.